{"id":2905,"date":"2021-01-27T14:12:21","date_gmt":"2021-01-27T14:12:21","guid":{"rendered":"https:\/\/dailyrapidnews.com\/eng\/?p=2905"},"modified":"2021-01-27T14:12:21","modified_gmt":"2021-01-27T14:12:21","slug":"lab-produced-antibody-new-hope-in-hiv-fight","status":"publish","type":"post","link":"https:\/\/dailyrapidnews.com\/eng\/2021\/01\/27\/lab-produced-antibody-new-hope-in-hiv-fight\/","title":{"rendered":"Lab-produced antibody, new hope in HIV fight"},"content":{"rendered":"<p>A large international study has shown that it is possible to prevent some HIV infections with infusions of a particularly potent protein known as a broadly neutralizing antibody, but it will likely take a combination of different and more potent proteins to block all strains of the shape-shifting virus.<\/p>\n<p>This follows promising results that show injecting broad neutralising antibodies (bNabs) in HIV-negative people has the potential to kill the\u00a0human immunodeficiency\u00a0virus before it infects the cells.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2907\" src=\"https:\/\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/rapid-news-rapidnews-Lab-produced-antibody-new-hope-in-HIV-fight-dailyrapidnews.jpg\" alt=\"rapid-news-rapidnews-Lab-produced-antibody-new-hope-in-HIV-fight-dailyrapidnews\" width=\"1067\" height=\"600\" srcset=\"https:\/\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/rapid-news-rapidnews-Lab-produced-antibody-new-hope-in-HIV-fight-dailyrapidnews.jpg 1067w, https:\/\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/rapid-news-rapidnews-Lab-produced-antibody-new-hope-in-HIV-fight-dailyrapidnews-300x169.jpg 300w, https:\/\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/rapid-news-rapidnews-Lab-produced-antibody-new-hope-in-HIV-fight-dailyrapidnews-1024x576.jpg 1024w, https:\/\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/rapid-news-rapidnews-Lab-produced-antibody-new-hope-in-HIV-fight-dailyrapidnews-768x432.jpg 768w\" sizes=\"auto, (max-width: 1067px) 100vw, 1067px\" \/><\/p>\n<p>On Tuesday, two proof-of-concept studies that tested an experimental antibody, VRC01, against HIV on more than 4,600 people raised the hopes of researchers after it achieved 75% protection in study participants during the 20-month study period.<\/p>\n<p>The AMP results include data from HVTN 704\/HPTN 085 which enrolled about 2,700 men and transgender people who have sex with men in the US, Brazil and Peru, and HVTN 703\/HPTN 081, which enrolled about 1,900 women from Africa.<\/p>\n<p>While traditionally vaccines are given to stimulate the immune system to make antibodies that can neutralise infectious viruses, with this approach, known as passive immunisation, participants were infused with the potent antibody at eight-week intervals over 80 weeks. AMP participants who received the antibody were 75% less likely to become infected, but the antibody was only effective against two strains of HIV, subtype C in Africa and subtype B in the other participating countries.<\/p>\n<blockquote class=\"twitter-tweet\">\n<p dir=\"ltr\" lang=\"en\">Antibody infusions prevent acquisition of some HIV strains, NIH studies find <a href=\"https:\/\/t.co\/KVkLz6qrE5\">https:\/\/t.co\/KVkLz6qrE5<\/a><\/p>\n<p>\u2014 Markian Hawryluk (@MarkianHawryluk) <a href=\"https:\/\/twitter.com\/MarkianHawryluk\/status\/1354075296123633664?ref_src=twsrc%5Etfw\">January 26, 2021<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><br \/>\nOverall its prevention efficacy was 26.6% among men and transgender people in the Americas, and only 8.8% among African women.<\/p>\n<p>However, in the 30% of cases where people were exposed to VRC01-sensitive strains, the rate of HIV acquisition was 0.20 per 100 person-years among people who received the bnAb, compared to 0.86 per 100 person-years among those who received the placebo. That means that, in this minority of participants, VRC01 was associated with a 75% drop in new infections.<\/p>\n<p>For comparison, daily oral Truvada or Descovy for pre-exposure prophylaxis (PrEP) are around 99% effective when used consistently, and once-monthly cabotegravir injections may be even more effective in real-world use.<\/p>\n<p>VRC01 was well tolerated in both trials. No safety concerns were identified, and adherence was high, Corey reported.<\/p>\n<p>Though not as successful as hoped in these studies, the results are a promising first step, according to Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health, which sponsored the trials.<\/p>\n<p>\u201cThese findings establish the concept that passive administration of a broadly neutralizing antibody can prevent acquisition of susceptible HIV strains,\u201d he said in a\u00a0press release. \u201cInsights gleaned from the AMP studies lay the foundation for future development of long-acting antibody-based HIV prevention tools and, ultimately, a vaccine.\u201d<\/p>\n<p>Corey said that he considers the study a success because the researchers were able to identify biomarkers and develop a laboratory test to predict whether an antibody would work against different strains of HIV and how much is needed for protection, providing tools to move the field forward.<\/p>\n<p>Since the AMP studies began, scientists have made progress on optimizing bNAbs to increase the number of HIV strains they can block, how strongly they bind to the virus, how long they last in the body and how efficiently they trigger an immune response against the virus itself and against HIV-infected cells. Potentially, these optimized bNAbs could be combined to develop a highly effective HIV prevention method, according to NIAID.<\/p>\n<p>Corey noted that antibodies are already in use for many diseases, including for prevention and treatment of COVID-19. He added that it might be possible to administer antibodies by subcutaneous or intramuscular injection rather than IV infusion, and the cost is dropping. \u201cI do think they will be economically feasible if they have high efficacy,\u201d he said.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A large international study has shown that it is possible to prevent some HIV infections<\/p>\n","protected":false},"author":1,"featured_media":2906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":""},"categories":[3],"tags":[],"class_list":["post-2905","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.4.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lab-Produced Antibody, New Hope in HIV Fight | Rapid News<\/title>\n<meta name=\"description\" content=\"A large 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href=\"https:\/\/dailyrapidnews.com\/eng\/category\/health\/\" rel=\"category tag\">Health<\/a>","tag_info":"Health","comment_count":"0","jetpack-related-posts":[{"id":7215,"url":"https:\/\/dailyrapidnews.com\/eng\/2021\/03\/23\/research-reveals-children-have-stronger-antibody-response-to-covid\/","url_meta":{"origin":2905,"position":0},"title":"Research reveals children have stronger antibody response to Covid","date":"March 23, 2021","format":false,"excerpt":"Children who are 10 and younger produce more antibodies in response to coronavirus infection than adolescents and adults, a study showed on Monday. 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The Secretary Wafaqi Mohtasib Secretariat (WMS) submitted its eighth implementation report in the Supreme Court regarding plight of inmates in jails, according to\u2026","rel":"","context":"In &quot;Editor's Picks&quot;","img":{"alt_text":"500-inmates-hundreds-suffering-from-covid-corona-virus-across-pakistan-jails-rapid-news-rapidnews-dailyrapidnews","src":"https:\/\/i0.wp.com\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/500-inmates-hundreds-suffering-from-covid-corona-virus-across-pakistan-jails-rapid-news-rapidnews-dailyrapidnews.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":2644,"url":"https:\/\/dailyrapidnews.com\/eng\/2021\/01\/25\/moderna-says-covid-19-vaccine-appears-to-be-effective-against-new-variants\/","url_meta":{"origin":2905,"position":3},"title":"Moderna says Covid-19 vaccine appears to be effective against new variants","date":"January 25, 2021","format":false,"excerpt":"Moderna said on Monday it plans to start clinical trials of an altered booster version of its Covid-19 vaccine aimed at the South African variant after tests showed its authorised vaccine may produce a diminished antibody response. It will also test an additional booster shot of its authorised vaccine in\u2026","rel":"","context":"In &quot;Health&quot;","img":{"alt_text":"moderna-vaccine-effective-against-south-african-UK-variants-rapid-news-rapidnews","src":"https:\/\/i0.wp.com\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/01\/moderna-vaccine-effective-against-south-african-UK-variants-rapid-news-rapidnews.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":18,"url":"https:\/\/dailyrapidnews.com\/eng\/2018\/07\/18\/the-man-who-saved-thousands-of-people-from-hiv\/","url_meta":{"origin":2905,"position":4},"title":"The man who saved thousands of people from HIV","date":"July 18, 2018","format":"image","excerpt":"Lorem ipsum dolor sit amet,sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, At vero eos et accusam et justo duo dolores et ea rebum. Lorem ipsum dolor sit amet, no sea takimata sanctus est Lorem ipsum dolor sit amet. 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However, what if there was a drug that would help people regenerate their former gnashers, rather\u2026","rel":"","context":"In &quot;Science&quot;","img":{"alt_text":"Scientists-Develop-New-Drug-That-Can-Regenerate-Lost-Teeth-rapidnews-dailyrapid","src":"https:\/\/i0.wp.com\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/04\/Scientists-Develop-New-Drug-That-Can-Regenerate-Lost-Teeth-rapidnews-dailyrapid.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts\/2905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/comments?post=2905"}],"version-history":[{"count":1,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts\/2905\/revisions"}],"predecessor-version":[{"id":2908,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts\/2905\/revisions\/2908"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/media\/2906"}],"wp:attachment":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/media?parent=2905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/categories?post=2905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/tags?post=2905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}