{"id":5661,"date":"2021-03-01T14:11:26","date_gmt":"2021-03-01T14:11:26","guid":{"rendered":"https:\/\/dailyrapidnews.com\/eng\/?p=5661"},"modified":"2021-03-01T14:11:26","modified_gmt":"2021-03-01T14:11:26","slug":"boosting-levels-of-this-protein-reduces-the-severity-of-covid-19-in-patients-reveals-new-study","status":"publish","type":"post","link":"https:\/\/dailyrapidnews.com\/eng\/2021\/03\/01\/boosting-levels-of-this-protein-reduces-the-severity-of-covid-19-in-patients-reveals-new-study\/","title":{"rendered":"Boosting Levels of this Protein Reduces the Severity of Covid-19 in Patients, Reveals New Study"},"content":{"rendered":"

Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19. Using drugs that boost OAS1 levels could be explored to try to improve these outcomes. The findings are published today in\u00a0Nature Medicine<\/em>.<\/p>\n

\"Lady-Davis-Institute-LDI-at-the-Jewish-General-Hospital-have-discovered-that-increased-levels-of-the-protein-OAS1-rapidnews-dailyrapid\"<\/p>\n

\u201cOur analysis shows evidence that OAS1 has a protective effect against COVID-19 susceptibility and severity,\u201d explains Dr. Brent Richards, a senior investigator at the LDI\u2019s Centre for Clinical Epidemiology and Professor of Medicine, Human Genetics, Epidemiology and Biostatistics at McGill University. \u201cThis is a very exciting development in the race to identify potential therapies to treat patients because there are already therapies in pre-clinical development that boost OAS1 and could be explored for their effect against SARS-CoV-2 infection.\u201d<\/p>\n

Understandably, a great deal of effort is being invested in vaccine development. However, with hundreds of millions of people already infected around the world, it is important not to neglect the search for disease-specific therapies since few such therapies have been identified. Moreover, given the prevalence of vaccine hesitancy in the community and uncertainty as to how long any vaccine will prove to be protective, COVID-19 is most probably going to be a global issue for years to come. Thus, the need for therapeutic treatments will continue.<\/p>\n

Researchers in Dr. Richards\u2019 lab explored proteins detectable in peripheral blood as a potential target. The challenge lay in determining which proteins play a causal role in disease progression, since their levels may also be influenced by COVID-19 itself or other confounding factors. Recent advances in proteomic technology \u2013 that is, the capacity to isolate and measure hundreds of circulating proteins at once \u2013 combined with genetic analyses through Mendelian randomization (MR) makes possible the delicate work of untangling which proteins affected COVID-19 adverse outcomes, rather than vice versa.<\/p>\n

\"neanderthal-hero-Lady-Davis-Institute-LDI-at-the-Jewish-General-Hospital-have-discovered-that-increased-levels-of-the-protein-OAS1-rapidnews-dailyrapid-dailyrapidnews\"<\/p>\n

From genetic determinants of 931 circulating proteins, Dr. Sirui Zhou, a post-doctoral fellow at the LDI and first author on the paper, found that increase in OAS1 levels was associated with reduced COVID-19 death or ventilation, hospitalization, and susceptibility in up to 14,134 COVID-19 cases and 1.2 million controls. The results were consistent in multiple sensitivity analyses. They proceeded to measure OAS1 levels in 504 patients with different COVID-19 outcomes from the Biobanque Qu\u00e9bec COVID-19, and found that increased OAS1 levels in post-infection patients were associated with protection against very severe COVID-19, hospitalization, and susceptibility.<\/p>\n

\u201cThe protective effect was particularly large,\u201d points out Dr. Zhou, \u201csuch that we observed a 50% decrease in the odds of very severe COVID-19 per standard deviation increase in OAS1 circulating levels. Interestingly, for non-African peoples, this protective effect is likely inherited from a Neanderthal derived form of OAS1 called p46.\u201d<\/p>\n

This form of OAS1 likely emerged in people of European ancestry through interbreeding with Neanderthals tens of thousands of years ago. Evolutionary pressure slowly increased the prevalence of this form of OAS1, such that it is now detectable in more than thirty-percent of people of European descent. It is likely that the form of the protein has served as protection against earlier pandemics.<\/p>\n

Because drug development, even in the accelerated environment of pandemic research, takes time it is particularly exciting that molecules which can increase OAS1 activity are currently in pre-clinical development for eventual deployment in clinical trials.<\/p>\n

\u201cOur recommendation is that those medications that trigger increased OAS1 levels be further studied for their effect on COVID-19 outcomes so that we may better treat infected patients,\u201d said Dr. Richards.<\/p>\n

This article has been republished from the following\u00a0materials<\/a>. Note: material may have been edited for length and content.<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that<\/p>\n","protected":false},"author":1,"featured_media":5662,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":""},"categories":[3,5],"tags":[],"class_list":["post-5661","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-science"],"yoast_head":"\nNeanderthal Protein May Reduce the Severity of COVID-19<\/title>\n<meta name=\"description\" content=\"Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that increased levels of the protein OAS1\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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Researchers pooled data from 51 studies involving a total of nearly 19,000 patients who were tracked for up to six months. The average follow-up was 77 days post-diagnosis. Overall, 27.4% reported sleep problems, 24.4% had fatigue, 20.2% scored\u2026","rel":"","context":"In "Health"","img":{"alt_text":"Neuropsychiatric-symptoms-persist-in-COVID-19-survivors-rapidnews-dailyrapid","src":"https:\/\/i0.wp.com\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/05\/Neuropsychiatric-symptoms-persist-in-COVID-19-survivors-rapidnews.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":11303,"url":"https:\/\/dailyrapidnews.com\/eng\/2021\/05\/27\/drug-makers-developing-medicines-to-cure-covid-19\/","url_meta":{"origin":5661,"position":4},"title":"Drug-makers developing medicines to cure COVID-19","date":"May 27, 2021","format":false,"excerpt":"Prevention is better than cure \u2014 but when it comes to Covid, what happens when people can\u2019t get the vaccine, don\u2019t want it, or they\u2019re immune suppressed and it fails to stop infection? The hunt is on for a coronavirus treatment that can be taken as a pill soon after\u2026","rel":"","context":"In "Health"","img":{"alt_text":"Drug-makers-developing-medicines-to-cure-COVID-19-rapidnews","src":"https:\/\/i0.wp.com\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/05\/Drug-makers-developing-medicines-to-cure-COVID-19-rapidnews-dailyrapid-e1622106498199.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":12523,"url":"https:\/\/dailyrapidnews.com\/eng\/2021\/12\/09\/severe-covid-infection-in-mothers-linked-to-preterm-births\/","url_meta":{"origin":5661,"position":5},"title":"Severe Covid Infection In Mothers Linked To Preterm Births","date":"December 9, 2021","format":false,"excerpt":"ISLAMABAD: A team of researchers has discovered that more severely a mother is infected with Covid-19, the more likely she is to experience preterm birth. The researchers reported that the rate of preterm birth in nearly 1,000 pregnant women, who tested positive for SARS-CoV-2, the virus that causes Covid-19, was\u2026","rel":"","context":"In "Pakistan"","img":{"alt_text":"pregnant_covid_vaccine","src":"https:\/\/i0.wp.com\/dailyrapidnews.com\/eng\/wp-content\/uploads\/2021\/12\/pregnant_covid_vaccine_500.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts\/5661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/comments?post=5661"}],"version-history":[{"count":2,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts\/5661\/revisions"}],"predecessor-version":[{"id":5667,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/posts\/5661\/revisions\/5667"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/media\/5662"}],"wp:attachment":[{"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/media?parent=5661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/categories?post=5661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailyrapidnews.com\/eng\/wp-json\/wp\/v2\/tags?post=5661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}