{"id":9412,"date":"2021-04-24T10:32:04","date_gmt":"2021-04-24T10:32:04","guid":{"rendered":"https:\/\/dailyrapidnews.com\/eng\/?p=9412"},"modified":"2021-04-24T10:32:04","modified_gmt":"2021-04-24T10:32:04","slug":"landmark-advance-as-malaria-vaccine-first-to-hit-who-goal","status":"publish","type":"post","link":"https:\/\/dailyrapidnews.com\/eng\/2021\/04\/24\/landmark-advance-as-malaria-vaccine-first-to-hit-who-goal\/","title":{"rendered":"‘Landmark’ advance as malaria vaccine first to hit WHO goal"},"content":{"rendered":"

LONDON: <\/strong><\/span>A new malaria vaccine has proven 77 per cent effective in trials on infants, British researchers said Friday, in what could prove to be a potential game-changer against the deadly mosquito-borne disease.<\/p>\n

In a clinical trial in Burkina Faso, the Matrix-M vaccine — developed by the University of Oxford’s Jenner Institute — was found to be 77 per cent effective after 450 infants inoculated in 2019 were followed up for a year, the Oxford researchers said in a statement.<\/p>\n

No serious adverse events were reported.<\/p>\n

\"Landmark-advance-as-malaria-vaccine-first-to-hit-WHO-goal-rapidnews-dailyrapid\"<\/p>\n

It is the first candidate vaccine for malaria to surpass a target set by the UN’s World Health Organisation, for researchers to create a jab of 75 per cent efficacy by 2030.<\/p>\n

A broader “Phase 3” trial involving 4,800 children will now be carried out in four African countries, in collaboration with the Serum Institute of India and the US pharmaceutical company Novavax.<\/p>\n

Professor Adrian Hill, head of the Jenner Institute — which developed the coronavirus vaccine now being distributed worldwide by Anglo-Swedish pharma giant AstraZeneca — said the test results marked “a great day” in the global fight against malaria.<\/p>\n

“We need to build on this, we need to keep all our ducks in a row, we need to avoid any safety signal, but I think the odds are now on our side, we can get this through,” he told the PA news agency.<\/p>\n

He pointed out that vaccines against Covid-19 were approved rapidly while the first trials for one against malaria date all the way back to the 1940s.<\/p>\n

Ahead of World Malaria Day on Sunday, the UN health agency has insisted that elimination of the disease that kills some 400,000 people each year around the globe is a “viable goal for all countries”.<\/p>\n

But a vaccine breakthrough remains key, and British Prime Minister Boris Johnson said the Oxford trial result was a “landmark achievement”.<\/p>\n

“Malaria kills hundreds of thousands of children a year. An effective vaccine holds out the possibility of ending this global tragedy,” he said on Twitter.<\/p>\n

– Children at greater risk –<\/p>\n

“Malaria killed at least four times as many more people in Africa last year as Covid did,” Hill said.<\/p>\n

“And nobody for a moment questioned whether Covid should have an emergency use review and authorisation in Africa — of course it did, very quickly.<\/p>\n

“So why shouldn’t a disease that firstly kills children rather than older people, certainly killed an awful lot more, be prioritised for emergency use authorisation in Africa?”<\/p>\n

The Serum Institute has committed to make at least 200 million doses annually, and Hill said Matrix-M “has the potential to have major public health impact if licensure is achieved”.<\/p>\n

The vaccine was given in a randomised trial involving 450 babies and toddlers aged five months to 17 months. A control group received a rabies vaccine instead.<\/p>\n

The infants received a booster vaccine after a year.<\/p>\n

Professor Charlemagne Ouedraogo, minister of health in Burkina Faso, said: “Malaria is one of the leading causes of childhood mortality in Africa.<\/p>\n

“We have been supporting trials of a range of new vaccine candidates in Burkina Faso and these new data show that licensure of a very useful new malaria vaccine could well happen in the coming years.<\/p>\n

“That would be an extremely important new tool for controlling malaria and saving many lives.”<\/p>\n

The results of the clinical trial were reported in a pre-print article on the website of the British medical journal The Lancet.<\/p>\n

\n
\n
<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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